Yes, you can play online slots for real money at licensed casinos in states with legal online casino gambling. These sites offer a wide range of options where players can bet and win real money. These winnings can then be withdrawn from the casino through various banking methods.
Most sessions on slot machines will result in losing money, and there's nothing you can do to chance that. Sometimes you'll win at slots, and even win big. Enjoy those times when they come. But never bet money you can't afford to lose, and be sure you're playing games that fit your bankroll.